The main objective of this work package is to design, generate and characterise several live attenuated measles-vectored vaccine candidates expressing immunogenic antigens from Zika virus.
Specifically it will:
- Select appropriately immunogenic antigens from Zika virus
- Express these antigens from mammalian expression plasmids for characterisation
- Insert these antigens into measles vector and generate recombinant viruses by reverse genetics
- Amplify and characterise in vitro these recombinant viruses
Institut Pasteur Paris (work package leader)
European Vaccine Initiative (EVI)